High-Throughput Identification of Gut Bacterial Cultivation Strategies

In this webinar, discover how PacBio HiFi sequencing is redefining microbiome research by replacing fragmented, short-read views with highly accurate long reads through full-length 16S rRNA gene sequencing and shotgun metagenomics to resolve species- and strain-level diversity, novel taxa, and functional potential within complex communities. Whether you're advancing microbiome therapeutics, mapping disease-associated signatures, or uncovering new microbial biology, learn how HiFi sequencing transforms complexity into clear, actionable insights in a single platform.

• How highly accurate full-length 16S rRNA sequencing provides species- and strain-level resolution, improving taxonomic accuracy and eliminating classification ambiguity common with other methods.
• How high-accuracy long-read metagenomics enables complete, strain-level metagenome-assembled genomes (MAGs), and how profiling improves taxonomic classifications, biosynthetic pathways, and antimicrobial resistance and functional gene annotations.
• How high-throughput testing of in vitro media enrichment conditions on fecal communities combined with sequencing can be used to inform isolation and cultivation strategies for diverse gut commensal species.
• How enrichment data can provide insight into the lifestyles of poorly characterized species.

Kinnex Full-length 16S sequencing enabled high-throughput examination of many growth conditions in a microbial enrichment experiment on a single sequencing run. The data generated enabled successful isolation of many species and improved our understanding of their metabolic preferences.